Sergio Ramos misses the welcome of Liverpool after sustaining a calf injury on international duty.
He joins Eden Hazard and Dani Carvajal but Federico Valverde has made the squad.
Casemiro missed the second leg with over Atalanta in the last round due to a ban, but is available, while Toni Kroos, who was a doubt for the welcome of Eibar, came off the bench in the 2-0 win and is fit to start.
Raphael Varane has returned a positive COVID-19 test, with Eder Militao expected to deputise.
Liverpool boss Jurgen Klopp remains without key quartet Joel Matip, Virgil van Dijk, Jordan Henderson and Joe Gomez.
Klopp could make a couple of changes from the XI that started the 3-0 win at Arsenal.
Georgino Wijnaldum should replace James Milner in the middle of the park, while Diogo Jota, who came off the bench to score twice at the Emirates, may lead the attack.
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